Ecommerce Taxation can be a complex and daunting process for online businesses. Strategies to help them navigate the complexities include conducting compliance assessments, investing in tax automation software, registering for VAT, collecting sales tax, maintaining impeccable records, consulting tax experts, staying up-to-date, and understanding cross-border implications. Challenges can include complexity, audit risks, and global reach, but with effective tax management, businesses can benefit from compliance, financial transparency, cost efficiency, and business growth.